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In type I allergy, allergen-specific IgE antibodies are formed upon initial (symptomless) contact.These bind to the surface of mast cells (histamine-rich cells that are present in all mucous membranes). The reaction occurs on second contact within seconds to a few minutes. In the case of allergies, antigens are free/dissolved molecules that are incorrectly viewed as threatening by the immune system. 

It is estimated that there are more than 80 recognized autoimmune diseases, with recent scientific evidence suggesting the existence of potentially more than 100 distinct conditions.[4][5][6] Nearly any body part can be involved