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Pathogenesis and diagnosis of type I allergy

In type I allergy, allergen-specific IgE antibodies are formed upon initial (symptomless) contact.These bind to the surface of mast cells (histamine-rich cells that are present in all mucous membranes). The reaction occurs on second contact within seconds to a few minutes. In the case of allergies, antigens are free/dissolved molecules that are incorrectly viewed as threatening by the immune system. 

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